Author

Muthiah Manoharan

Alnylam Pharmaceuticals (United States)ORCID 0000-0002-7931-1172Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Jayanta KunduiD· 2 shared David R. CoreyiD· 1 shared Dhrubajyoti DattaiD· 1 shared Dipanwita Banerjee· 1 shared Eric T. KooliD· 1 shared Jiaxin HuiD· 1 shared Lu XiaoiD· 1 shared Martin EgliiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiophysics

Jayanta KunduORCID

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2 papers

Recent·Most cited

BiophysicsACS Central SciencePeer-reviewedOct 28, 2025

C-Nucleosides Stabilize RNA by Reducing Nucleophilicity at 2'-OH

Dipanwita Banerjee, Lu Xiao, Pavitra S. Thacker…·Eric T. Kool

This paper investigates how C-nucleoside modifications in RNA reduce nucleophilicity at the 2'-OH position, thereby stabilizing RNA against cleavage.

7 citations

experimental assay

𝕏 PostBluesky

BiochemistrybioRxivPreprintMar 11, 2025

Modulation of TTR Gene Expression in the Eye using Modified Duplex RNAs

Jiaxin Hu, Xin Gong, Jayanta Kundu…·David R. Corey

This study shows lipid-modified siRNAs can inhibit TTR gene expression in the eye via intravitreal injection, suggesting a potential therapy for ocular TTR amyloidosis.

DOI 10.1101/2025.03.11.642595

humanbulk RNA-seq

𝕏 PostBluesky