Modifications to the gut microbiome alter bone matrix proteomics and fracture toughness at the cellular scale
Natasha K. Hunt, Chongshan Liu, J. Liu, Q. Tang, S.J. Stephen, Bo Wang, Charles A. Schurman, Christopher D. King, Q. Liu, D. Vashisth, Birgit Schilling, M. Hassani, Christopher J. Hernandez
This paper shows that altering the gut microbiome changes bone matrix proteomics and reduces fracture toughness, with micropillar splitting as a precise method to measure these effects.
bioRxiv · Nov 21, 2025 · PreprintBioengineering