Charles A. Schurman

Alzheimer's disease risk factor APOE4 exerts dimorphic effects on female bone

This study shows APOE4 affects female bone quality more than male bone, without structural changes, by disrupting osteocyte function.

Statistical Principles Define an Open-Source Differential Analysis Workflow for Mass Spectrometry Imaging Experiments with Complex Designs

Age-related Delays in Osteochondral Remodeling of Fracture Healing Illustrated by Mass Spectrometry Imaging

The paper uses spatial proteomics to show age-related delays in fracture healing by analyzing extracellular matrix composition in young and aged mice.

Tissue and Extracellular Matrix Remodeling of the Subchondral Bone during Osteoarthritis of Knee Joints as revealed by Spatial Mass Spectrometry Imaging

This study uses spatial mass spectrometry imaging to identify ECM peptide markers distinguishing OA-affected subchondral bone from healthy tissue and less affected regions.

Modifications to the gut microbiome alter bone matrix proteomics and fracture toughness at the cellular scale

This paper shows that altering the gut microbiome changes bone matrix proteomics and reduces fracture toughness, with micropillar splitting as a precise method to measure these effects.

Investigation of Neurons and Microglia from APOE3 Induced Pluripotent Stem Cells using Data-Independent Acquisitions on a ZenoTOF 7600

This paper develops a proteomic workflow using data-independent acquisitions to analyze APOE3-derived neurons and microglia, identifying cell type-specific markers and pathways.

Multiplexed Targeted iprm-PASEF Assays for MALDI Mass Spectrometry Imaging of Lipids, NAD+ 2 , and Related Metabolites in CD38 Knockout Mice

The paper introduces iprm-PASEF, a targeted MSI method, to identify and quantify metabolites and lipids in CD38 knockout mice, showing increased NAD+ and decreased ADPR.

Intervertebral disc impairments in a mouse model of Alzheimer's Disease

This study examines intervertebral disc (IVD) impairments in a mouse model of Alzheimer's Disease, finding no increased degeneration but altered mechanical properties and volume.