ATF4 programs proline-dependent immune evasion in β-Catenin-driven hepatocellular carcinoma
Stefany Infante, Eva Santa María, Alexander Finnemore, Sergio Barace, Angel Martinez-Montes, Francesco Damone, Sara Arcelus, Guillermo García-Porrero, Nastaransadat Hosseini, Eduardo Miraval, Carlos E. de Andrea, Diana Llópiz, María Reig, Yaron Finkelstein, Bruno Sangro, , Josepmaria Argemí
This study identifies ATF4 as a key driver of immune evasion in β-catenin-driven hepatocellular carcinoma by programming a proline-dependent metabolic axis that suppresses anti-tumor immunity.
bioRxiv · May 16, 2026 · PreprintCancer Biology