Cell BiologybioRxivPreprint
Germline BRCA1 Mutation Deregulates Irradiation-Induced Cell Cycle Checkpoints in Human Mammary Luminal Progenitors
Abhijith Kuttanamkuzhi, Bowen Zhang, Kelvin Yeung…·Rama Khokha
This study shows that BRCA1 mutations impair the G1/S checkpoint in luminal progenitors, altering their response to irradiation stress compared to basal cells.
DOI 10.64898/2026.08.11.743512