Rama Khokha

This study shows that BRCA1 mutations impair the G1/S checkpoint in luminal progenitors, altering their response to irradiation stress compared to basal cells.

This paper uses N-glycoproteomics to analyze patient-derived xenografts, identifies FAT2 as a therapeutic target for head and neck cancers, and validates its role in tumor growth and CAR T cell activity.

The paper profiles proteomic and functional features of mammary epithelial cells in high-risk women, showing how clinical factors influence cellular composition and tumor risk.

This study shows that medium-chain fatty acid exposure in non-transformed mammary glands induces aging-like changes linked to breast cancer risk.

The paper identifies PR-expressing basal cells and PR-primed progenitors, redefining mammary epithelial hierarchy and challenging existing models of breast biology and cancer.

The paper shows that lipid metabolism, specifically through OA, shifts metabolic pathways in breast cells, increasing SAM and 2-HG, which contribute to oncogenic properties and epigenetic changes.

This study identifies stress granules as critical for AML stem cell survival and stress adaptation, revealing their role in gene regulation and potential as therapeutic targets.