Author

Pirashaanthy Tharmapalan

University Health Network

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:human· 3 Approach:experimental assay· 2 Assay:proteomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Hal K. BermaniD· 3 shared Matthew WaasiD· 3 shared Rama KhokhaiD· 3 shared Thomas KislingeriD· 3 shared Abhijith KuttanamkuzhiiD· 2 shared Curtis W. McCloskeyiD· 2 shared Olivia Drummond Guy· 2 shared Paul D. WaterhouseiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersCell Biology

Hal K. BermanORCID

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Author profile →

3 papers

Recent·Most cited

Germline BRCA1 Mutation Deregulates Irradiation-Induced Cell Cycle Checkpoints in Human Mammary Luminal Progenitors

Abhijith Kuttanamkuzhi, Bowen Zhang, Kelvin Yeung, Matthew Waas, Pirashaanthy Tharmapalan, Soumili Sarkar, Curtis W. McCloskey, Olivia Drummond Guy, Hui Fang, Shreya Mishra, Thomas Kislinger, Hal K. Berman, Shane M. Harding, Rama Khokha

This study shows that BRCA1 mutations impair the G1/S checkpoint in luminal progenitors, altering their response to irradiation stress compared to basal cells.

bioRxiv · Aug 12, 2026 · PreprintCell Biology

Mapping lineage and functional diversity in the high-risk human mammary epithelium

Matthew Waas, Bowen Zhang, Meinusha Govindarajan, Pirashaanthy Tharmapalan, Abhijith Kuttanamkuzhi, Olivia Drummond Guy, Michael Woolman, Hal K. Berman, Paul D. Waterhouse, Rama Khokha, Thomas Kislinger

The paper profiles proteomic and functional features of mammary epithelial cells in high-risk women, showing how clinical factors influence cellular composition and tumor risk.

bioRxiv · Jan 13, 2026 · PreprintCancer Biology

Progesterone Receptor Expressing Basal Cells and Progesterone Receptor-Primed Progenitors Redefine the Mammary Epithelial Hierarchy

Pirashaanthy Tharmapalan, Matthew Waas, Curtis W. McCloskey, Virginie Defamie, Kazeera Aliar, Bruno M. Simões, Robert B. Clarke, Sacha Jon Howell, Thomas Kislinger, Hal K. Berman, Paul D. Waterhouse, Rama Khokha

The paper identifies PR-expressing basal cells and PR-primed progenitors, redefining mammary epithelial hierarchy and challenging existing models of breast biology and cancer.

bioRxiv · Apr 16, 2025 · PreprintCell Biology