Tau in the brain interstitial fluid is fragmented and seeding-competent
Erica Barini, Gudrun Plotzky, Yulia Mordashova, Jonas Hoppe, Esther Rodriguez-Correa, Sonja Julier, Florie Le Prieult, Ina Mairhofer, Mario Mezler, Sandra Biesinger, Miroslav Cik, Marcus W. Meinhardt, Ebru Ercan-Herbst, Dagmar E. Ehrnhoefer, Andreas Striebinger, , Kerstin Schlegel
This study identifies fragmented, phosphorylated Tau in brain interstitial fluid from Tau transgenic mice and shows that only a subset of these fragments can seed Tau aggregation in vitro.
Neurobiology of Aging · Sep 17, 2021Peer-reviewedNeuroscience