Marcus W. Meinhardt

Multi-Lab Testing of Early Preclinical Discoveries Identifies Promising Treatments

The paper evaluates multi-laboratory studies to identify promising treatments by assessing effect sizes and experimental rigor across different medical fields.

Epigenome-wide Association Study of Psilocybin-Induced Methylome Changes in Alcohol Use Disorder

This study identifies DNA methylation changes in AUD patients after psilocybin treatment, finding significant CpG sites and methylation patterns linked to neuroplasticity and immune functions.

Sex and age specific effects on the development of addiction and compulsive-like drinking in rats

This study investigates sex and age differences in addiction and compulsive-like drinking behavior in rats using an alcohol deprivation effect model.

Tau in the brain interstitial fluid is fragmented and seeding-competent

This study identifies fragmented, phosphorylated Tau in brain interstitial fluid from Tau transgenic mice and shows that only a subset of these fragments can seed Tau aggregation in vitro.

Adverse Social Experiences in Adolescent Rats Results in Persisting Sex-Dependent Effects on Alcohol-Seeking Behavior

This study shows that adolescent peer-rejection in rats leads to lasting sex-dependent changes in alcohol-seeking behavior, with females showing increased reinstatement and males decreased reinstatement.

A common molecular mechanism for cognitive deficits and craving in alcoholism

This study identifies a common molecular mechanism involving mGluR2 dysfunction linking cognitive deficits and alcohol craving, and develops a biomarker for targeted interventions.