Ebru Ercan-Herbst

Tau in the brain interstitial fluid is fragmented and seeding-competent

This study identifies fragmented, phosphorylated Tau in brain interstitial fluid from Tau transgenic mice and shows that only a subset of these fragments can seed Tau aggregation in vitro.

SETD7-mediated lysine monomethylation is abundant on non-hyperphosphorylated nuclear Tau

The paper identifies lysine monomethylation on Tau by SETD7 in human brain tissue and shows its association with nuclear Tau in a mouse model of tauopathy.

A post-translational modification signature defines changes in soluble tau correlating with oligomerization in early stage Alzheimer’s disease brain

The paper identifies specific phosphorylation sites on soluble tau oligomers in early Alzheimer’s disease that differ from those in neurofibrillary tangles.

Asparagine endopeptidase cleaves tau at N167 after uptake into microglia

The paper identifies a novel tau cleavage site at N167 by AEP in microglia, showing it is part of a proteolytic cascade leading to tau degradation, not accumulation.