Non-canonical regulation of the plasma membrane copper transporter CTR1 through modulation of membrane mechanical properties
Arnab Gupta, Bidisha Sinha, Durba Sengupta, Subhendu Kumar Chatterjee, Sumanta Kar, Siddhanta V. Nikte, Tisha Dash, Saptarshi Maji, Tanmoy Ghosh
This study identifies a non-canonical receptor-like mechanism where CTR1 clusters on the plasma membrane in response to copper, modulating membrane properties to facilitate endocytosis.
bioRxiv · Mar 28, 2025 · PreprintCell Biology