Author

Stefan A. Hoffmann

University of ManchesterORCID 0000-0002-3184-8640Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:yeast· 2 Assay:CRISPR screen· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Yizhi CaiiD· 2 shared Anthony P. GreeniD· 1 shared Ewan R. MoodyiD· 1 shared James SandersiD· 1 shared Mark McCulloughiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersSynthetic Biology

Yizhi CaiORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Synthetic yeast genome SCRaMbLEing uncovers a new role for ribosomal proteins in genetic code expansion

James Sanders, Stefan A. Hoffmann, Ewan R. Moody, Mark McCullough, Anthony P. Green, Yizhi Cai

The paper improves orthogonal translation in yeast by enhancing a pyrrolysyl-tRNA synthetase system and identifies ribosomal protein deletions that increase non-canonical amino acid incorporation.

bioRxiv · Aug 31, 2025 · PreprintSynthetic Biology

Engineering stringent genetic biocontainment of yeast with a protein stability switch

Stefan A. Hoffmann, Yizhi Cai

The paper develops a genetic biocontainment system for yeast using a protein stability switch, identifying essential genes that can be conditionally stabilized with estradiol to achieve stringent containment.

Nature Communications · Feb 5, 2024Peer-reviewedSynthetic Biology