Synthetic BiologybioRxivPreprint
Synthetic yeast genome SCRaMbLEing uncovers a new role for ribosomal proteins in genetic code expansion
James Sanders, Stefan A. Hoffmann, Ewan R. Moody…·Yizhi Cai
The paper improves orthogonal translation in yeast by enhancing a pyrrolysyl-tRNA synthetase system and identifies ribosomal protein deletions that increase non-canonical amino acid incorporation.
DOI 10.1101/2025.08.31.673356