Cryo-ET reveals nanoscale thick filamentdisorganization in MYH7 P710R hypertrophiccardiomyopathy cardiomyocytes
Magda Zaoralová, Joseph Yoniles, Prerna Giri, Richard G. Held, Alison Schroer Vander Roest, Peter D. Dahlberg, Daniel Bernstein, Alexander R. Dunn, Leeya Engel
This study uses cryo-ET to show that MYH7 P710R mutations disrupt thick filament organization in HCM cardiomyocytes, leading to sarcomeric disarray and ribosome infiltration.
bioRxiv · Feb 18, 2026 · PreprintCell Biology