Alison Schroer Vander Roest

Beta-Adrenergic Stimulation and MYH7 G256E Mutant Gene Dosage Drive Hypertrophic Cardiomyopathy Phenotype Penetrance

This study investigates factors influencing HCM phenotype penetrance by comparing MYH7 mutations in isogenic hiPSC-CMs and shows that beta-adrenergic stimulation and gene dosage affect disease expression.

Cryo-ET reveals nanoscale thick filamentdisorganization in MYH7 P710R hypertrophiccardiomyopathy cardiomyocytes

This study uses cryo-ET to show that MYH7 P710R mutations disrupt thick filament organization in HCM cardiomyocytes, leading to sarcomeric disarray and ribosome infiltration.

Kinetic Modeling of mant-ATP Turnover to Interpret the Biochemically Defined Myosin SRX State

This paper develops a kinetic model to interpret mant-ATP fluorescence decay in myosin SRX state measurements, showing that decay phases result from label redistribution, not equilibrium states.

YAP dysregulation triggers hypertrophy by CCN2 secretion and TGFβ uptake in human pluripotent stem cell-derived cardiomyocytes

This study shows that YAP overactivation in HCM mutant cardiomyocytes drives hypertrophy via CCN2 secretion and TGFβ uptake.

Multi-scale models reveal hypertrophic cardiomyopathy MYH7 G256E mutation drives hypercontractility and elevated mitochondrial respiration

This study investigates the effects of the MYH7 G256E mutation on myosin function across multiple scales, finding increased hypercontractility and mitochondrial respiration.

CADHERIN-11 BLOCKADE REDUCES INFLAMMATION DRIVEN FIBROTIC REMODELING AND IMPROVES OUTCOMES AFTER MYOCARDIAL INFARCTION

This study shows that blocking CDH11 reduces inflammation-driven fibrosis and improves cardiac function after myocardial infarction in mice.