Cell BiologyThe EMBO JournalPeer-reviewed
C9orf72/SMCR8 complex maintains microglial homeostasis via RAB8A-ESCRT-mediated lysosomal repair
Shan Li, Shidong Xu, Feng Li…·Mei Yang
This study identifies the C9orf72/SMCR8 complex as essential for microglial lysosomal repair and homeostasis, revealing its role in preventing neuroinflammation through RAB8A-ESCRT pathways.
DOI 10.1038/s44318-026-00817-w