Penghui Zhang

C9orf72/SMCR8 complex maintains microglial homeostasis via RAB8A-ESCRT-mediated lysosomal repair

This study identifies the C9orf72/SMCR8 complex as essential for microglial lysosomal repair and homeostasis, revealing its role in preventing neuroinflammation through RAB8A-ESCRT pathways.

Intraperitoneal programming of tailored CAR macrophages via mRNA-LNP to boost cancer immunotherapy

This study develops an mRNA-LNP delivery system to program CAR-Ms in vivo, showing enhanced antitumor effects through immune activation and synergy with PD-1/L1 therapy.

Programmable Aptamer-Embedded Circular RNAs for Targeted Antigen-Presenting Cells Immunotherapy

This paper develops Apt-circRNAs for targeted antigen-presenting cell immunotherapy, showing efficacy in tumors and clinical trials.

Spatiotemporal transcriptomic analyses reveal molecular gradient patterning during development and the tonotopic organization along cochlear axis

The paper constructs a single-cell-resolution spatial transcriptomic atlas of mouse cochlear development, revealing molecular gradients and tonotopic organization along the cochlear axis.

Rfx3 controls outer hair cell differentiation, maintenance, and hair bundle formation by regulating the expression of Insm1, Ikzf2, and Triobp genes

This study identifies Rfx3's role in outer hair cell development by regulating Insm1, Ikzf2, and Triobp through transcriptional activation and repression.