PRC1 and CTCF-Mediated Transition from Poised to Active Chromatin Loops Drives Bivalent Gene Activation
Aflah Hanafiah, Zhuangzhuang Geng, Tingting Liu, Yen Teng Tai, Wenjie Cai, Qiang Wang, Neil David Christensen, Yan Liu, Feng Yue, Zhonghua Gao
The paper identifies PRC1 and CTCF's role in forming chromatin loops that maintain bivalent genes in a poised state for activation during differentiation.
bioRxiv · Nov 13, 2024 · PreprintGenomics