Interpretable transcriptome-to-phenotype modeling of cell-painting nuclear morphology features from RNA-seq under low-dose radiation exposure
Sanket R. Jantre, Kriti Chopra, Guang Zhao, Clark A. Cucinell, Rebecca Weinberg, Sara Forrester, Thomas Scott Brettin, Nathan M. Urban, Xiaoning Qian, Byung-Jun Yoon
The paper models how low-dose radiation affects nuclear morphology by linking RNA-seq data to cell-painting imaging features over time using an interpretable inverse modeling framework.
bioRxiv · Feb 23, 2026 · PreprintBioinformatics