Author

Lucy Anne Doyle

MRC Centre for Regenerative MedicineORCID 0000-0002-3232-0629Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1

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Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Alex von KriegsheimiD· 1 shared Alexandra Derrien· 1 shared Chinmayi PednekariD· 1 shared Dipta SenguptaiD· 1 shared Firuze Ünlü BektaşiD· 1 shared Ian R. AdamsiD· 1 shared Jennifer LawsoniD· 1 shared Robert Scott IllingworthiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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1 shared paperMolecular Biology

Alex von KriegsheimORCID

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1 paper

Recent·Most cited

H2AK119ub Safeguards Against Ectopic Transcription Factor Mediated Gene Activation in the Developing Forebrain

Lucy Anne Doyle, Alexandra Derrien, Dipta Sengupta, Firuze Ünlü Bektaş, Jennifer Lawson, Chinmayi Pednekar, Alex von Kriegsheim, Ian R. Adams, Robert Scott Illingworth

This study shows that H2AK119ub, catalyzed by PRC1, prevents ectopic gene activation by transcription factors during neural differentiation, ensuring proper cell fate restriction in the developing forebrain.

bioRxiv · Jul 7, 2025 · PreprintMolecular Biology