Chinmayi Pednekar

mTORC2 stabilizes HIF-1β to coordinate metabolic adaptation in lung cancer

This study identifies mTORC2 as a convergent dependency in lung cancer that stabilizes HIF-1β to drive metabolic adaptation and tumor progression, revealing a therapeutic target in sphingolipid metabolism.

ER-liquid condensate contacts sequester FAM134B/C and RhoA to govern cell morphology

The paper identifies ER-liquid condensates that sequester FAM134B/C and RhoA, affecting cell morphology and cancer invasion.

Ubiquitin recognition integrates plant immune signaling by cell-surface and intracellular receptors

This study identifies ubiquitin recognition as the mechanism enabling mutual potentiation between cell-surface and intracellular receptors in plant immunity.

JMJD5 regulates metabolism by hydroxylating ISY1, and regulating the Arginine Methyltransferase PRMT6

This paper identifies JMJD5-ISY1-PRMT6 as a pathway regulating metabolism by hydroxylating ISY1 to inhibit PRMT6, showing its role in liver cancer and potential as a therapeutic target.

FAK modulates glioblastoma stem cell energetics via regulation of glycolysis and glutamine oxidation

This study shows FAK regulates glycolysis and glutamine oxidation in glioblastoma stem cells, affecting mitochondrial morphology and cell migration.

H2AK119ub Safeguards Against Ectopic Transcription Factor Mediated Gene Activation in the Developing Forebrain

This study shows that H2AK119ub, catalyzed by PRC1, prevents ectopic gene activation by transcription factors during neural differentiation, ensuring proper cell fate restriction in the developing forebrain.