A compound that directly and selectively stalls PCSK9 translation
Nathanael G. Lintner, Kim F. McClure, Donna N. Petersen, Allyn T. Londregan, David W. Piotrowski, Liuqing Wei, Jun Xiao, Michael W. Bolt, Paula M. Loria, Bruce A. Maguire, Kieran F. Geoghegan, Austin Huang, Tim Rolph, Spiros I. Liras, Jennifer A. Doudna, , Jamie H. D. Cate
A compound inhibits PCSK9 translation by stalling ribosomes at codon 34, reducing plasma PCSK9 and cholesterol in rats.
PLoS Biology · Mar 21, 2017Peer-reviewedSystems Biology