GeneticsbioRxivPreprint
Lipid nanoparticles incorporating a GalNAc ligand enable in vivo liver ANGPTL3 editing in wild-type and somatic LDLR knockout non-human primates
Lisa N. Kasiewicz, Souvik Biswas, Aaron Beach…·Andrew M. Bellinger
This study develops GalNAc-LNPs for liver gene editing in NHPs, achieving high editing efficiency and ANGPTL3 reduction in both HoFH and wild-type models.
5 citations