Inferring the composition of a mixed culture of natural microbial isolates by deep sequencing
Mark Voorhies, Bastian Joehnk, Jessie Uehling, Keith Walcott, Claire A. Dubin, Heather Mead, Christina M. Homer, John N. Galgiani, Bridget M. Barker, Rachel B. Brem, Anita Sil
The paper develops a method to infer strain composition in microbial mixed cultures using natural SNPs as barcodes, validated on Coccidioides posadasii isolates and applied to GWAS.
bioRxiv · Aug 5, 2024 · PreprintGenetics