A molecularly engineered lectin destroys EGFR and inhibits the growth of non-small cell lung cancer
Susana M. Chan, Zoe Raglow, Anupama Pal, Scott D. Gitlin, Maureen Legendre, Dafydd G. Thomas, Ranjit Kumar Mehta, Mingjia Tan, Mukesh Kumar Nyati, Alnawaz Rehemtulla, David M. Markovitz
This paper demonstrates that the engineered lectin H84T binds to and inhibits NSCLC cell growth by lysosomal degradation of EGFR, independent of EGFR mutation status.
bioRxiv · Mar 18, 2024 · PreprintCancer Biology