Single Nucleus Multiome Analysis Reveals Early Inflammatory Response to High-Fat Diet in Mouse Pancreatic Islets
Isabell Victoria Strandby Ernst, Lasse Lehtonen, Sille Marie Nilsson, Freja Louise Nielsen, Ann-Britt Marcher, Susanne Mandrup, Jesper Grud Skat Madsen
The paper uses single nucleus multiomics to study early inflammatory responses in mouse pancreatic islets under high-fat diet, finding proinflammatory gene activation and reduced beta-cell identity.
bioRxiv · Apr 1, 2025 · PreprintCell Biology