Annotation of the non-canonical translatome reveals that CHO cell microproteins are a new class of mAb drug product impurity
Marina Castro‐Rivadeneyra, Ioanna Tzani, Paul S. Kelly, Lisa Strasser, Felipe Guapo, Ciara Tierney, Michelle Chain, Lin Zhang, MARTIN M. CLYNES, Barry L. Karger, Niall Barron, Jonathan Bones, Colin Clarke
The paper identifies microprotein impurities in mAb drug products from CHO cells using Ribo-seq and mass spectrometry, showing their abundance varies with growth phase.
bioRxiv · Jan 20, 2022 · PreprintGenomics