Crispant analysis in zebrafish as a tool for rapid functional screening of disease-causing genes for bone fragility
Sophie Debaenst, Tamara Jarayseh, Hanna De Saffel, Jan Willem Bek, Matthieu Boone, Iván Josipovic, Pierre Kibleur, Ronald Young Kwon, Paul J. Coucke, Andy Willaert
This study uses zebrafish crispant screening to functionally validate disease-causing genes for bone fragility disorders, showing consistent skeletal phenotypes and differential gene expression in affected models.
eLife · Jan 16, 2025Peer-reviewedGenetics