Decoding Phenotypic Variability in Osteogenesis Imperfecta: Zebrafish as a Model for Molecular and Ultrastructural Insights.
Sophie Debaenst, Lauren Sahd, Caitlin Debaene, Tamara Jarayseh, Hanna De Saffel, Jan Willem Bek, Wouter Steyaert, Delphi Van Haver, Sara Dufour, Francis Impens, Paul J. Coucke, Adelbert De Clercq, Andy Willaert
This study uses zebrafish models to link genetic mutations in type I collagen to phenotypic severity in OI, identifying biomarkers and mechanisms of variability.
bioRxiv · Jan 28, 2025 · PreprintMolecular Biology