Ronald Young Kwon

This study develops fully automated methods using FIJI/ImageJ to compute body morphometric measures from microCT scans of adult zebrafish, improving throughput and reducing variability.

This study uses zebrafish crispant screening to functionally validate disease-causing genes for bone fragility disorders, showing consistent skeletal phenotypes and differential gene expression in affected models.

This study investigates the role of cped1 in zebrafish bone and lean mass, finding no significant effects on these traits despite loss of function.

The paper identifies transcriptomically distinct microglia populations in Alzheimer's disease and aged human brains using single-nucleus RNA-seq and trajectory inference.

This study evaluates a semi-automated tool to quantify craniofacial variations in zebrafish models of human skeletal diseases, finding phenotypic differences for four genes and parallels to human symptoms for two.

This paper shows that wnt16 regulates spine and muscle morphogenesis in zebrafish through signals from notochord and dermomyotome, explaining its dual role in bone and muscle traits.

This paper uses computational anatomy to quantify 3D craniofacial phenotypes in zebrafish mutants, identifying shape differences in bmp1a mutants.

This study uses scRNA-seq to analyze MET and EMT programs in zebrafish fin regeneration, showing co-expression of EMT markers in dedifferentiating and differentiating osteoblastic cells.

This paper identifies spatial phenotypic patterns in zebrafish somatic mutants using deep phenotyping and statistical frameworks to improve discrimination of mutant populations.

This study shows that the Reissner fiber, secreted by the subcomissural organ in zebrafish, is essential for spine morphogenesis and its loss leads to scoliosis.

This study shows zebrafish mutants with type I collagen mutations closely mimic human collagenopathies, revealing phenotypic variability linked to disease severity and potential for identifying genetic modifiers.

This study uses microCT to analyze zebrafish skeletons, identifying phenotypes linked to human diseases and showing how deep phenotyping improves mutant discrimination.