Author

Xiangyun Lu

First Affiliated Hospital Zhejiang UniversityORCID 0000-0002-3380-7527Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Biophysics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Assay:cryo-EM· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Hangping YaoiD· 2 shared Nanping WuiD· 2 shared Chaoyu CheniD· 1 shared Danrong Shi· 1 shared Dong-Shan Yu· 1 shared Dongyang DongiD· 1 shared Fumin LiuiD· 1 shared Haibo WuiD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBiophysics

Hangping YaoORCID

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Author profile →

3 papers

Recent·Most cited

Cryo-ET of IgG bivalent binding on SARS-CoV-2 provides structural basis for antibody avidity

Hangping Yao, Yutong Song, Qi Huang, Miaojin Zhu, Jiaming Liang, Zheyuan Zhang, Xiaodi Zhang, Dongyang Dong, Danrong Shi, Zhigang Wu, Xiangyun Lu, Haibo Wu, Yong Chen, Sai Li

This study uses cryo-ET to examine how two IgGs bind to SARS-CoV-2 S-trimers, revealing structural mechanisms of bivalent binding and antibody avidity.

Nature Communications · Apr 11, 2026Peer-reviewedBiophysics

HSC70, HSPA1A, and HSP90AB1 Facilitate Ebola Virus trVLPs to Induce Autophagy

Dong-Shan Yu, Shu-Hao Yao, Wen-Na Xi, Linfang Cheng, Fumin Liu, Haibo Wu, Xiangyun Lu, Nanping Wu, Shui-Lin Sun, Hangping Yao

This study shows that EBOV-trVLPs induce autophagy via CMA, and HSC70, HSPA1A, and HSP90AB1 are required for this process.

bioRxiv · Jun 22, 2020 · PreprintMolecular Biology

CD4 T-cell transcriptome expression reversal of the lncRNA-mRNA co-expression network in elite controller vs. normal-process HIV patients

Chaoyu Chen, Xiangyun Lu, Nanping Wu

The paper identifies differentially expressed lncRNAs and mRNAs in elite controller HIV patients compared to normal-process patients and constructs their co-expression network, revealing potential regulatory relationships.

bioRxiv · Apr 11, 2019 · PreprintBioinformatics