SARS-CoV-2 spike protein unlikely to bind to integrins via the Arg-Gly-Asp (RGD) motif of the Receptor Binding Domain: evidence from structural analysis and microscale accelerated molecular dynamics
Houcemeddine Othman, Haifa Ben Messaoud, Oussema Khamessi, Hazem Ben Mabrouk, Kaïs Ghedira, Avani Bharuthram, Florette Kathleen Treurnicht, Ikechukwu Achilonu, Yasien Sayed, Najet Srairi‐Abid
This study investigates whether the RGD motif in SARS-CoV-2 RBD can bind integrins using structural analysis and simulations, finding no significant conformational changes or interaction capability.
Frontiers in Molecular Biosciences · Feb 14, 2022Peer-reviewedBioinformatics