Author

Houcemeddine Othman

University of the WitwatersrandORCID 0000-0002-1159-6482Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 3 Genetic & Genomic Medicine· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 4 Assay:protein structure· 3 Research Focus:protein structure prediction· 3 Approach:simulation· 2 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

Jorge da RochaiD· 4 shared Scott HazelhurstiD· 4 shared Caroline T. TiemesseniD· 2 shared Clement AdebamowoiD· 2 shared Francisco‐Javier GamoiD· 2 shared Gerrit BothaiD· 2 shared Gustave SimoiD· 2 shared Jean‐Tristan BrandenburgiD· 2 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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4 shared papersBioinformatics

Jorge da RochaORCID

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5 papers

Recent·Most cited

BioinformaticsFrontiers in Molecular BiosciencesPeer-reviewedFeb 14, 2022

SARS-CoV-2 spike protein unlikely to bind to integrins via the Arg-Gly-Asp (RGD) motif of the Receptor Binding Domain: evidence from structural analysis and microscale accelerated molecular dynamics

Houcemeddine Othman, Haifa Ben Messaoud, Oussema Khamessi…·Najet Srairi‐Abid

This study investigates whether the RGD motif in SARS-CoV-2 RBD can bind integrins using structural analysis and simulations, finding no significant conformational changes or interaction capability.

22 citations

protein structurestatistical model

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Genetic & Genomic MedicineThe Pharmacogenomics JournalPeer-reviewedJul 23, 2021

G6PD variant distribution in sub-Saharan Africa and potential risks ofusing chloroquine/hydroxychloroquine based treatments forCOVID-19

Jorge da Rocha, Houcemeddine Othman, Caroline T. Tiemessen…·Scott Hazelhurst

The paper analyzes G6PD variant distribution in sub-Saharan Africa and highlights potential risks of using chloroquine/hydroxychloroquine for COVID-19 due to G6PD deficiency.

26 citations

humanwhole-genome sequencing

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BioinformaticsInternational Journal of Molecular SciencesPeer-reviewedJul 21, 2021

Single nucleotide polymorphism induces divergent dynamic patterns in CYP3A5: a microsecond scale biomolecular simulation of variants identified in Sub-Saharan African populations

Houcemeddine Othman, Jorge da Rocha, Scott Hazelhurst

This study uses molecular dynamics simulations to analyze the impact of rare CYP3A5 variants from Sub-Saharan African populations on protein structure and drug binding.

4 citations

humanprotein structure

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GeneticsbioRxivPreprintJun 14, 2020

The extent and impact of variation in ADME genes in sub-Saharan African populations

Jorge da Rocha, Houcemeddine Othman, Gerrit Botha…·Scott Hazelhurst

This study characterizes ADME gene variation in sub-Saharan African populations, identifying novel variants and highlighting the need for tailored pharmacogenomic approaches.

7 citations

humanwhole-genome sequencing

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BioinformaticsBiochemical and Biophysical Research CommunicationsPeer-reviewedMay 14, 2020

Interaction of the spike protein RBD from SARS-CoV-2 with ACE2: similarity with SARS-CoV, hot-spot analysis and effect of the receptor polymorphism

Houcemeddine Othman, Zied Bouslama, Jean‐Tristan Brandenburg…·Scott Hazelhurst

The paper analyzes the interaction between SARS-CoV-2 RBD and ACE2, identifies key residues for binding, and assesses the impact of ACE2 variants on this interaction.

146 citationstop 3%

humanprotein structure

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