Rocky Lai

The paper profiles mouse CD4+ T cells across >700 samples to identify 20 molecular states, revealing diverse effector functions and unexpected similarities between Tfh and chronically stimulated states.

immgenT creates a comprehensive T-cell molecular atlas across mouse organs and disease states, identifying 8 lineages and 107 clusters using deep generative models and integrating external datasets.

This study shows BCG vaccination protects against Mtb infection in CC042 mice through two T cell-dependent phases: an early innate response and a later effector T cell response.

The paper identifies CD226 as a marker distinguishing effector from dysfunctional CD8+ T cells in Mtb infection and shows its role in costimulating recognition of Mtb-infected macrophages.

The paper identifies TCR-V gene usage patterns in T cells sorted by anti-TCR mAbs using single-cell RNAseq and finds enriched ERV1-family LTR expression in specific TRBV regions.

The paper examines T cell changes in mammary glands during pregnancy and lactation, finding an expansion of T effector cells and similarities to intestinal T cells.