Samuel M. Behar

Human memory CD4+ T cells recognize non-infected macrophage bystanders exposed to Mycobacterium tuberculosis-infected cells

The paper shows human memory CD4+ T cells recognize both Mtb-infected and bystander macrophages, with some TCRs specifically recognizing infected cells.

immgenT CD4: A Reference Landscape of Mouse CD4+ T Cells

The paper profiles mouse CD4+ T cells across >700 samples to identify 20 molecular states, revealing diverse effector functions and unexpected similarities between Tfh and chronically stimulated states.

immgenT: A Comprehensive Reference of Convergent T-cell States in the Mouse

immgenT creates a comprehensive T-cell molecular atlas across mouse organs and disease states, identifying 8 lineages and 107 clusters using deep generative models and integrating external datasets.

A comprehensive reference of mouse CD8αβ T cell differentiation states

The paper establishes immgenT-CD8 as a comprehensive reference for mouse CD8αβ T cell differentiation states across diverse immunological contexts.

BCG vaccination elicits protection against Mtb infection mediated by two phases of T cell immunity

This study shows BCG vaccination protects against Mtb infection in CC042 mice through two T cell-dependent phases: an early innate response and a later effector T cell response.

Type I interferon-driven lung pathology restricts T cell accumulation and motility during tuberculosis

This study shows that type I interferon signaling in tuberculosis restricts T cell accumulation and motility by altering lung pathology and T cell states.

CD226 identifies effector CD8+ T cells during tuberculosis and costimulates recognition of Mycobacterium tuberculosis-infected macrophages

The paper identifies CD226 as a marker distinguishing effector from dysfunctional CD8+ T cells in Mtb infection and shows its role in costimulating recognition of Mtb-infected macrophages.

NRF2 inhibition of alveolar macrophage MHC II expression during Mycobacterium tuberculosis infection

This study shows NRF2 inhibits MHC II expression in alveolar macrophages during Mtb infection, impairing CD4+ T cell activation and host immunity.

Genomic Specificity of Anti-TCR mAbs determined by single-cell RNAseq

The paper identifies TCR-V gene usage patterns in T cells sorted by anti-TCR mAbs using single-cell RNAseq and finds enriched ERV1-family LTR expression in specific TRBV regions.

Expansion of mammary intraepithelial lymphocytes and intestinal inputs shape T cell dynamics in lactogenesis

The paper examines T cell changes in mammary glands during pregnancy and lactation, finding an expansion of T effector cells and similarities to intestinal T cells.

CD4 T cell dysfunction is associated with bacterial recrudescence during chronic tuberculosis.

This study investigates CD4 T cell dysfunction in chronic tuberculosis and links it to bacterial recrudescence in mice.