NeurosciencebioRxivPreprint
Loss of TREM2 reduces hyperactivation of progranulin deficient microglia but not lysosomal pathology
Anika Reifschneider, Sophie Robinson, Bettina van Lengerich…·Christian Haass
This study shows that TREM2 deficiency reduces microglial hyperactivation in GRN-deficient models but does not rescue lysosomal dysfunction or neurodegeneration biomarkers.
2 citations