Author

Bettina van Lengerich

Denali Therapeutics (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Anika ReifschneideriD· 2 shared Anja CapelliD· 2 shared Arthur LiesziD· 2 shared Brigitte NuscheriD· 2 shared Christian HaassiD· 2 shared Gilbert Di PaoloiD· 2 shared Joseph W. LewcockiD· 2 shared Jung H. SuhiD· 2 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Anika ReifschneiderORCID

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2 papers

Recent·Most cited

TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism

Astrid Feiten, Kilian Dahm, Kai Schlepckow, Bettina van Lengerich, Jung H. Suh, Anika Reifschneider, Benedikt Wefers, Laura M. Bartos, Karin Wind-Mark, Lis de Weerd, T Ulas, Elena De Domenico, Pia Grundschöttel, Stefan Paulusch, Benjamin Tast, , Christian Haass

This study investigates how TREM2 expression levels affect microglial function, metabolism, and response to TREM2 agonists in a mouse model of Alzheimer's disease.

Nature Communications · Jan 24, 2026Peer-reviewedNeuroscience

Loss of TREM2 reduces hyperactivation of progranulin deficient microglia but not lysosomal pathology

Anika Reifschneider, Sophie Robinson, Bettina van Lengerich, Johannes S. Gnörich, Todd Logan, Steffanie Heindl, Miriam Annika Vogt, Endy Weidinger, Lina Riedl, Karin Wind-Mark, Artem Zatcepin, Sophie Haberl, Brigitte Nuscher, Gernot Kleinberger, Julien Klimmt, , Christian Haass

This study shows that TREM2 deficiency reduces microglial hyperactivation in GRN-deficient models but does not rescue lysosomal dysfunction or neurodegeneration biomarkers.

bioRxiv · Jul 8, 2021 · PreprintNeuroscience