Author

Nikolay A. Aleksashin

Innovative Genomics InstituteORCID 0000-0002-3403-7587Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Jamie H. D. CateiD· 2 shared Rohan R. Shelke· 2 shared Tianhao Yin· 2 shared Conner J. LangebergiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

4 top collaborators · 6 mutual co-author links

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2 shared papersBiochemistry

Jamie H. D. CateORCID

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2 papers

Recent·Most cited

Overcoming the eIF2α Brake in Human Cell-Derived Translation Systems

Nikolay A. Aleksashin, Rohan R. Shelke, Tianhao Yin, Jamie H. D. Cate

This paper identifies eIF2 phosphorylation as a major barrier to translation in human cell-derived systems and presents strategies to overcome it through genome editing or expression-based rescue.

bioRxiv · Nov 16, 2025 · PreprintBiochemistry

RNA elements required for the high efficiency of West Nile Virus-induced ribosomal frameshifting

Nikolay A. Aleksashin, Conner J. Langeberg, Rohan R. Shelke, Tianhao Yin, Jamie H. D. Cate

This study identifies RNA elements critical for high-efficiency ribosomal frameshifting in West Nile Virus, revealing structural and sequence requirements and implications for antiviral strategies.

Nucleic Acids Research · Dec 4, 2024Peer-reviewedMolecular Biology