Author

Shadisadat Esmaeili

Fred Hutch Cancer CenterORCID 0000-0002-3411-3834Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 1 Approach:mechanistic / dynamical model· 1 Organism:rat· 1 Approach:statistical model· 1

Frequent Co-Authors

Joshua Tisdell SchifferiD· 2 shared David A. SwaniD· 1 shared Katherine L. OwensiD· 1 shared Keith R. JeromeiD· 1 shared Marius WalteriD· 1 shared Ugo Avila-Ponce de LeóniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 9 mutual co-author links

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2 shared papersSystems Biology

Joshua Tisdell SchifferORCID

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2 papers

Recent·Most cited

Systems BiologyAntimicrobial Agents and ChemotherapyPeer-reviewedAug 5, 2026

Plasma nirmatrelvir and molnupiravir concentrations required for inhibition of SARS CoV-2 replication differ between rhesus macaques and humans

Ugo Avila-Ponce de León, Shadisadat Esmaeili, Katherine L. Owens, Joshua Tisdell Schiffer

The paper models drug efficacy in rhesus macaques and humans to show differences in required plasma concentrations for antiviral activity against SARS-CoV-2.

1 citationtop 4%

ratstatistical model

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MicrobiologybioRxivPreprintMay 13, 2025

Intracellular and extracellular dynamics of herpes simplex virus 1 DNA and infectious particles in epithelial and neuronal cells

Shadisadat Esmaeili, David A. Swan, Keith R. Jerome…·Marius Walter

This study models HSV-1 dynamics in epithelial and neuronal cells under low and high MOI, revealing differences in eclipse phase duration, egress rates, and productive infection kinetics.

DOI 10.1101/2025.05.13.653775

humanmechanistic / dynamical model

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