Keith R. Jerome

Regulatory T cells restrain cytotoxic and bystander CD8 T cells without compromising antigen-driven memory in mucosal tissue

The paper investigates how regulatory T cells control cytotoxic and bystander CD8 T cell activity in mucosal tissues without affecting antigen-driven memory responses.

Herpes simplex virus 1 strain 17+ with R2 mutation in UL37 has residual retrograde transport

This study shows that the R2 mutation in UL37 of HSV-1 strain 17+ only partially blocks retrograde transport, allowing latency and reactivation in mouse models.

Genital herpes shedding episodes associate with alterations in the spatial organization and activation of mucosal immune cells

This study examines how HSV-2 shedding affects immune cell organization and gene expression in the vaginal mucosa, finding increased immune surveillance and potential tissue homeostasis mechanisms.

Intracellular and extracellular dynamics of herpes simplex virus 1 DNA and infectious particles in epithelial and neuronal cells

This study models HSV-1 dynamics in epithelial and neuronal cells under low and high MOI, revealing differences in eclipse phase duration, egress rates, and productive infection kinetics.

Variant mutation in SARS-CoV-2 nucleocapsid enhances viral infection via altered genomic encapsidation

The paper identifies a mutation in the SARS-CoV-2 nucleocapsid protein that enhances viral infection by promoting dimer formation and altering virion structure.

Pooled CAR-T screening in nonhuman primates identifies designs with enhanced proliferation, trafficking, and persistence

This study screens CAR-T designs in nonhuman primates and identifies MyD88-CD40 costimulatory domains as superior for proliferation, trafficking, and persistence.

NF-κB dependent gene expression and plasma IL-1β, TNFα and GCSF drive transcriptomic diversity and CD4:CD8 ratio in people with HIV on ART.

This study identifies transcriptomic clusters in HIV patients on ART linked to immune recovery and inflammation markers, revealing novel subgroups with distinct immunological profiles.

Minimization of gene editing off-target effects by tissue restriction of expression

This study shows that restricting meganuclease expression to specific tissues reduces off-target gene editing in vivo.

Differences in expression of tumor suppressor, innate immune, inflammasome, and potassium/gap junction channel host genes significantly predict viral reservoir size during treated HIV infection

This study identifies host gene expression patterns associated with HIV reservoir size in treated individuals, linking inflammation, innate immunity, and potassium/gap junction channels to viral persistence.

AAV-delivered gene editing for latent genital or orofacial herpes simplex virus infection reduces ganglionic viral load and minimizes subsequent viral shedding in mice

This study shows that AAV-delivered gene editing reduces latent HSV DNA in mice and decreases viral shedding, with some toxicity observed at high doses.

Tracking SARS-CoV-2 Spike Protein Mutations in the United States (2020/01 - 2021/03) Using a Statistical Learning Strategy

The paper uses a statistical learning strategy to track SARS-CoV-2 Spike protein mutations in the US, identifying new variants and their spatiotemporal patterns.

Host Variation in Type I Interferon Signaling Genes (MX1), CCR5{triangleup}32, and MHC Class I Alleles in Treated HIV+ Non-Controllers Predict Viral Reservoir Size

The paper investigates host genetic variations in MX1, CCR5Δ32, and MHC class I alleles in HIV+ non-controllers on ART and finds associations with HIV reservoir size.

In silico detection of SARS-CoV-2 specific B-cell epitopes and validation in ELISA for serological diagnosis of COVID-19

The paper predicts SARS-CoV-2 B-cell epitopes using computational methods and validates them with ELISA, finding two antigens with high sensitivity and specificity for serological diagnosis of COVID-19.

Herpes Simplex Virus Mistyping due to HSV-1 x HSV-2 Interspecies Recombination in Viral Gene Encoding Glycoprotein B

The paper reports a case of HSV mistyping caused by HSV-1 x HSV-2 recombination in the UL27 gene, which is important for diagnostics and therapeutics.

Inherited chromosomally integrated HHV-6 demonstrates tissue-specific RNA expression in vivo that correlates with increased antibody immune response.

This study identifies tissue-specific RNA expression of integrated HHV-6A/B in vivo and links it to increased antibody responses against specific viral antigens.

The impact of interspecies recombination on human herpes simplex virus evolution and host immune recognition

This study identifies interspecies recombination events in HSV-2 genomes and shows their impact on genetic variation and T-cell recognition.

RNA sequencing of the in vivo human herpesvirus 6B transcriptome to identify targets for clinical assays distinguishing between latent and active infections

This study uses RNA sequencing to analyze HHV-6B transcriptomes in various samples to identify diagnostic targets distinguishing latent from active infections.

Viral diversity is an obligate consideration in CRISPR/Cas9 designs for HIV cure

This paper identifies highly-conserved CRISPR guide RNAs for HIV cure and models the impact of viral diversity on therapeutic success.

Ultrasensitive capture of human herpes simplex virus genomes directly from clinical samples reveals extraordinarily limited evolution in cell culture

The paper develops tools to directly sequence HSV genomes from clinical samples with high sensitivity and low viral load, revealing limited evolution during cell culture.

Copy number heterogeneity, large origin tandem repeats, and interspecies recombination in HHV-6A and HHV-6B reference strains

The paper uses next-generation sequencing to analyze copy number variations and interspecies recombination in HHV-6A and HHV-6B reference strains, revealing large tandem repeats and a novel recombinant strain.

Myeloablation-associated deletion of ORF4 in a human coronavirus 229E infection

The paper reports a large genomic deletion in human coronavirus 229E associated with myeloablation in a patient undergoing hematopoietic cell transplantation.