Katherine L. Owens

The paper models how delayed immune responses and prolonged infections increase the transmission risk of SARS-CoV-2 variants with fitness-enhancing mutations.

The paper models drug efficacy in rhesus macaques and humans to show differences in required plasma concentrations for antiviral activity against SARS-CoV-2.

The paper uses a multiparent yeast population to identify QTL for growth rates across environments, revealing context-dependent genetic architectures and allelic heterogeneity.

This study develops a spatiotemporal model to simulate CAR T-cell therapy in solid tumors, showing that local administration is most effective against slow-growing, highly diffusive tumors with low cell density.

The paper predicts the functional effect of compound heterozygous genotypes using a yeast-based assay and a linear model applied to variant effect maps.