NeuroscienceScience AdvancesPeer-reviewed
FUS-ALS mutants alter FMRP phase separation equilibrium and impair protein translation
Nicol Birsa, Agnieszka M Ule, Maria Giovanna Garone…·Pietro Fratta
This study shows that FUS-ALS mutants form cytoplasmic condensates that alter FMRP phase separation, leading to translation inhibition in motor neurons.