Gabriella Viero

The paper shows that ribosome quality control via ZNF598 degradation helps aneuploid cells survive proteotoxic stress, with ZNF598 expression linked to tumor aneuploidy.

This study presents a spatiotemporal multi-omics analysis of aging neuromuscular junctions in mice, identifying genes with decoupled transcript and protein trajectories and highlighting post-transcriptional regulation in NMJ aging.

RiboWich improves ribosome profiling by eliminating ribosome purification and enabling high-throughput, low-input translatome analysis.

The paper introduces Cell Marker Accordion, a tool for accurate and interpretable single-cell and spatial omics annotation across health and disease contexts.

The paper identifies COL1A1 as a translation-specific biomarker of SMA severity and shows it can be rescued by SMN-restoring therapies in multiple models.

This study investigates how TDP-43 dysregulation disrupts protein synthesis in ALS models by altering ribosome dynamics and mRNA homeostasis, revealing a conserved mechanism across in vitro and in vivo systems.

The paper analyzes responses to SMN2 splice-modifying treatments in SMA fibroblasts, finding variability in treatment efficacy based on patient-specific factors.

This study characterizes two TDP-43 proteinopathy models in mouse neurons, revealing reduced axonal translation, increased oxidative stress, and presynaptic dysfunction linked to mRNA metabolism disruption.

The paper introduces expressyouRcell, an R package that visualizes gene expression and protein level changes across time and space using dynamic cellular pictographs.

The paper introduces circAID-p-seq, a PCR-free method for phospho-RNA sequencing, and demonstrates its application in ribosome profiling to study RNA-protein interactions.

This study shows that FUS-ALS mutants form cytoplasmic condensates that alter FMRP phase separation, leading to translation inhibition in motor neurons.

The paper shows SMN protein binds ribosomes and modulates translation of specific mRNAs in SMA, causing translational defects in motor neuron-related proteins.

The paper identifies Hfq-mediated sRNA-target interactions in E. coli that facilitate adaptation to nutrient availability changes.

riboWaltz optimizes P-site positioning in ribosome profiling data, improving accuracy and visualization of ribosome locations compared to existing tools.

The paper introduces RiboLace, a method to isolate active ribosomes for ribosome profiling, enabling high-resolution analysis of active translation.

The paper identifies early translational defects in SMA mice, showing reduced translational efficiency and ribosome numbers in motor neurons, which are rescued by SMN restoration.