Author

Brian Tsang

University of TorontoORCID 0000-0002-7615-5397Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Julie Deborah Forman-KayiD· 2 shared Agnieszka M UleiD· 1 shared Alessandro RosaiD· 1 shared Anny DevoyiD· 1 shared Cristian BodoiD· 1 shared Elizabeth FisheriD· 1 shared Francesca MattediiD· 1 shared Gabriella VieroiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiochemistry

Julie Deborah Forman-KayORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Competing effects modulate the rate of poly(A) RNA deadenylation in a biomolecular condensate

Rose Irwin, Robert W. Harkness V, Brian Tsang, Zi Hao Liu, Kunyang Sun, Tian Hao Huang, Teresa L. Head-Gordon, Lewis E. Kay, Julie Deborah Forman-Kay

The paper investigates how competing factors in biomolecular condensates modulate the rate of poly(A) RNA deadenylation by CNOT7, revealing concentration-dependent increases and diffusion-related decreases in enzymatic efficiency.

bioRxiv · Jul 6, 2026 · PreprintBiochemistry

FUS-ALS mutants alter FMRP phase separation equilibrium and impair protein translation

Nicol Birsa, Agnieszka M Ule, Maria Giovanna Garone, Brian Tsang, Francesca Mattedi, P. Andrew Chong, Jack Humphrey, Seth Jarvis, Melis Pisiren, Oscar G. Wilkins, Michael L. Nosella, Anny Devoy, Cristian Bodo, Rafaela Fernandez de la Fuente, Elizabeth Fisher, , Pietro Fratta

This study shows that FUS-ALS mutants form cytoplasmic condensates that alter FMRP phase separation, leading to translation inhibition in motor neurons.

Science Advances · Jul 21, 2021Peer-reviewedNeuroscience