Author

David J. Smith

University of BirminghamORCID 0000-0002-3427-0936Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Organism:zebrafish· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:simulation· 1 Approach:statistical model· 1

Frequent Co-Authors

Meurig T. GallagheriD· 2 shared Adán GuerreroiD· 1 shared Advait Veeraghanta· 1 shared Basudha BasuiD· 1 shared Bernard D. KeavneyiD· 1 shared Catarina BotaiD· 1 shared Charlie F RowlandsiD· 1 shared Colin A. JohnsoniD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersDevelopmental Biology

Meurig T. GallagherORCID

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3 papers

Recent·Most cited

Developmental BiologybioRxivPreprintMay 22, 2025

The RNA splicing factor PRPF8 is required for left-right organiser cilia differentiation and determination of cardiac left-right asymmetry via regulation of Arl13b splicing

Fangfei Jiang, Michael Boylan, Dale W. Maxwell…·Kathryn E. Hentges

This study identifies PRPF8 as essential for left-right organiser cilia function and cardiac asymmetry by regulating ARL13B splicing in mice and zebrafish.

DOI 10.1101/2025.05.22.654869

mousezebrafish

𝕏 PostBluesky

Developmental BiologyeLifePeer-reviewedJun 28, 2023

Fluid extraction from the left-right organizer uncovers mechanical properties needed for symmetry breaking

Pedro Sampaio, Sara Pestana, Catarina Bota…·Susana S. Lopes

The paper investigates the role of fluid mechanics in left-right symmetry breaking during zebrafish embryo development and finds that mechanosensing, not fluid content, drives this process.

10 citations

zebrafishexperimental assay

𝕏 PostBluesky

Developmental BiologyPhilosophical Transactions of the Royal Society B Biological SciencesPeer-reviewedDec 30, 2019

Simulations of particle tracking in the oligociliated mouse node and implications for left-right symmetry breaking mechanics

Meurig T. Gallagher, Thomas D. Montenegro‐Johnson, David J. Smith

The paper simulates particle transport in the mouse node to assess how cilia-driven flow might lead to left-right asymmetry, finding that uniform random release best matches experimental data.

11 citations

mousesimulation

𝕏 PostBluesky