Author

Basudha Basu

University of LeedsORCID 0000-0002-5434-5202Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1

Frequent Co-Authors

Colin A. JohnsoniD· 3 shared Dapeng WangiD· 2 shared Katarzyna SzymańskaiD· 2 shared Kathryn E. HentgesiD· 2 shared Louise A. StepheniD· 2 shared Michael Boylan· 2 shared Nouf J. AlthaliiD· 2 shared Wasay Mohiuddin Shaikh Qureshi· 2 shared

Activity by Year

2017-2026 · peak 1/yr

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10 top collaborators · 37 mutual co-author links

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3 shared papersDevelopmental Biology

Colin A. JohnsonORCID

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3 papers

Recent·Most cited

Prpf8N1531S homozygous mutant mouse embryos have multiple defects in cardiac development and show aberrant splicing of the cardiac transcription factor Tead1

Wasay Mohiuddin Shaikh Qureshi, Haoxiang Zhou, Abigail Bennington, Nouf J. Althali, Anna van der Zwaluw, Michael Boylan, Louise A. Stephen, Kashish Jain, Basudha Basu, Dapeng Wang, Colin A. Johnson, Kathryn E. Hentges

This study identifies a critical role for Prpf8 in cardiac development through aberrant splicing of Tead1 and disrupted Notch signaling in Prpf8N1531S homozygous mutant mice.

bioRxiv · Apr 21, 2026 · PreprintDevelopmental Biology

The RNA splicing factor PRPF8 is required for left-right organiser cilia differentiation and determination of cardiac left-right asymmetry via regulation of Arl13b splicing

Fangfei Jiang, Michael Boylan, Dale W. Maxwell, Wasay Mohiuddin Shaikh Qureshi, Charlie F Rowlands, Gennadiy Tenin, Karen Mitchell, Louise A. Stephen, Elton J. R. Vasconcelos, Dapeng Wang, Tong Chen, Junzhe Zha, Jingshu Liu, Nouf J. Althali, Dragoș-Vasile Leordean, , Kathryn E. Hentges

This study identifies PRPF8 as essential for left-right organiser cilia function and cardiac asymmetry by regulating ARL13B splicing in mice and zebrafish.

bioRxiv · May 22, 2025 · PreprintDevelopmental Biology

Human iPSC-derived RPE and retinal organoids reveal impaired alternative splicing of genes involved in pre-mRNA splicing in PRPF31 autosomal dominant retinitis pigmentosa

Adriana Buskin, Lili Zhu, Valeria Chichagova, Basudha Basu, Sina Mozaffari‐Jovin, David Dolan, Alastair Droop, Joseph Collin, Revital Bronstein, Sudeep Mehrotra, Michael H. Farkas, Gerrit Hilgen, Kathryn White, Dean Hallam, Katarzyna Bialas, , Majlinda Lako

The paper generates patient-specific retinal organoids and RPE from RP type 11 patients to show PRPF31 mutations cause retinal-specific splicing defects and structural/functional impairments, which are corrected by in situ gene editing.

bioRxiv · Dec 11, 2017 · PreprintGenetics