Structured Pooling Improves Detection of Rare Regulatory Mutations in Population-Scale Reporter Assays
Katherine Dura, Keith Siklenka, Kari Strouse, Shauna Morrow, Chuangchuang Zhang, Alejandro Barrera, Andrew S. Allen, Timothy E. Reddy, William H. Majoros
The paper introduces a structured pooling method for population-scale STARR-seq experiments, improving detection of rare regulatory variants by increasing signal-to-noise ratio and providing Bayesian effect size estimates.
bioRxiv · Mar 31, 2026 · PreprintBioinformatics