Chuangchuang Zhang

The paper identifies multi-enhancer regulatory hubs critical for Th17 cell identity by analyzing chromatin accessibility and enhancer function in mouse CD4+ T cell subsets.

The paper introduces a structured pooling method for population-scale STARR-seq experiments, improving detection of rare regulatory variants by increasing signal-to-noise ratio and providing Bayesian effect size estimates.

This study uses MRI and fluorescence imaging to show impaired glymphatic function in a mouse model of Huntington disease, suggesting it as a potential biomarker and therapeutic target.

This study shows that HTT silencing in premanifest HD mice delays disease onset and slows progression, using CBVa as a noninvasive biomarker.