Author

Scott J. Barraza

PTC Therapeutics (United States)ORCID 0000-0002-3459-1780Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Christopher R. TrottaiD· 2 shared Angela Minnella· 1 shared Brian Kosmyna· 1 shared Christie MorrilliD· 1 shared Elisabetta MoriniiD· 1 shared Ellen M. WelchiD· 1 shared Hannah Lindmeier· 1 shared Jairo Sierra· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBiochemistry

Christopher R. TrottaORCID

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2 papers

Recent·Most cited

BiochemistryNature CommunicationsPeer-reviewedJul 16, 2026

The U1 snRNP protein U1C and Helix H of U1 snRNA are critical for small molecule splicing modulator function

Zhiling Kuang, Brian Kosmyna, Xueni Li…·Rui Zhao

This study shows that U1C and Helix H of U1 snRNA are essential for branaplam's effect on weak 5 splice site recognition, while risdiplam requires additional factors for activity.

2 citations

spatial transcriptomicsexperimental assay

𝕏 PostBluesky

NeurosciencebioRxivPreprintMay 6, 2025

MAPT Splicing Modulators as a Therapeutic Strategy for Tauopathies

M. Catarina Silva, Hannah Lindmeier, Paolo Pigini…·Elisabetta Morini

Discovery of SMCs that correct MAPT splicing, reduce 4R tau, and rescue pathology in patient-derived neuronal and in vivo models of 4R tauopathies.

1 citation

humanmouse

𝕏 PostBluesky