Author

Clayton K. Collings

Broad InstituteORCID 0000-0002-3471-2132Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Alexandra L. GhabeniD· 1 shared Austin MooreiD· 1 shared Cemre CeleniD· 1 shared Cigall KadochiD· 1 shared Donald W. LittleiD· 1 shared Gianna Maggiore· 1 shared Hao ZhuiD· 1 shared Ibrahim NassouriD· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperGenetics

Alexandra L. GhabenORCID

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2 papers

Recent·Most cited

Arid1a loss potentiates pancreatic β-cell regeneration through activation of EGF signaling

Cemre Celen, Jen-Chieh Chuang, Shunli Shen, Lin Li, Gianna Maggiore, Yuemeng Jia, Xin Luo, Austin Moore, Yunguan Wang, Jordan E. Otto, Clayton K. Collings, Zixi Wang, Xuxu Sun, Ibrahim Nassour, Ji Young Park, , Hao Zhu

This study shows that Arid1a loss enhances pancreatic β-cell regeneration by activating EGF signaling, protecting against diabetes.

Cell Reports · Nov 1, 2022Peer-reviewedGenetics

HIV chromatin is a preferred target for drugs that bind in the DNA minor groove

Clayton K. Collings, Donald W. Little, Samuel J. Schafer, John N. Anderson

The paper shows that minor groove binding drugs preferentially disrupt HIV chromatin in vitro and in vivo due to the high A-tract content in HIV DNA.

PLoS ONE · Dec 30, 2019Peer-reviewedMolecular Biology